Sodium Hydroxide → HCID 67193625, compound

Participants

Reaction Steps

To a solution of methyl 4-[(2S,4R)-1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]benzoate (for a preparation see Intermediate 107) (20 mg, 0.047 mmol) in ethanol (0.5 mL) was added NaOH (1M in water, 0.188 mL, 0.188 mmol) and the resulting mixture was stirred at room temperature for 3 h then concentrated in vacuo. Purification of the residue using MDAP gave 4-[(2S,4R)-1-acetyl-2-methyl-4-({[(1-methylethyl)oxy]carbonyl}amino)-1,2,3,4-tetrahydro-6-quinolinyl]benzoic acid (12 mg, 0.029 mmol, 62%) as a white solid.

Provenance & Evidence