Hydrochloric Acid → Hydrochloric Acid

HRID 2367043Notes

Reaction equation

HRID 2367043 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([N:17]3[CH2:21][CH2:20][C@H:19]([NH:22]C(=O)OC(C)(C)C)[CH2:18]3)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=1.[ClH:32]>O1CCOCC1>[F:31][C:2]([F:1])([F:30])[C:3]1[N:8]=[C:7]([N:9]2[CH2:10][CH2:11][CH:12]([C:15]([N:17]3[CH2:21][CH2:20][C@H:19]([NH2:22])[CH2:18]3)=[O:16])[CH2:13][CH2:14]2)[CH:6]=[CH:5][CH:4]=1.[ClH:32]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57803327tert-Butyl [(3S)-1-({1-[6-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}carbonyl)pyrrolidin-3-yl]carbamate

Product 2

HCID 313Hydrochloric AcidHCID 57803348(3S)-1-({1-[6-(Trifluoromethyl)pyridin-2-yl]piperidin-4-yl}carbonyl)pyrrolidin-3-amine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl [(3S)-1-({1-[6-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}carbonyl)pyrrolidin-3-yl]carbamate (1.3 g, 2.9 mmol) was dissolved in a 4 M solution of HCl in 1,4-dioxane (10 mL). After being stirred at room temperature for 1 hr, the solution was concentrated to give the desired product as HCl salt (0.6 g). MS (M+H) 343.1.

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-c3f4e455882c4e7da7d8fd126e46e02e
Source dataset
uspto-grants-2014_04
Patent number
US08697870B2

Reaction notes

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