Water → HCID 66616023, compound

HRID 2367061Notes

Reaction equation

HRID 2367061 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([CH3:15])([CH3:14])[C:10]([O:12]C)=[O:11].[OH-].[K+].O>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([CH3:15])([CH3:14])[C:10]([OH:12])=[O:11]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 66616086HCID 66616086, compound

Product 1

HCID 66616023HCID 66616023, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 2-(2-bromo-5-fluorophenyl)-2-methylpropanoate (0.529 g, 3.12 mmol, J. Am. Chem. Soc., 2008, 130, 15157-15166), potassium hydroxide (3.2 g, 57 mmol), water (10 mL) and ethanol (30 mL) was refluxed for 20 h.

Workup

  1. temperaturewas refluxed for 20 h.

Sources & evidence

ORD record
ord-1129d3c7b01547968a2863e9f7d37db0
Source dataset
uspto-grants-2014_04
Patent number
US08697877B2

Reaction notes

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