HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2367162Generated: October 30, 2026
Pyridine → 3-Carbamoylisoxazol-5-ylmethyl 4-nitrophenyl carbonate
https://huagongshe.com/reaction/2367162
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | 5-(Hydroxymethyl)-1,2-oxazole-3-carboxamide | HCID 8027246 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Carbamoylisoxazol-5-ylmethyl 4-nitrophenyl carbonate | HCID 66660860 | — |
Reaction Steps
To a solution of 2.0 g (14.07 mmol) of 3-carbamoylisoxazol-5-ylmethanol, 1.71 ml (21.11 mmol) of pyridine and 0.17 g (1.41 mmol) of N,N-dimethylaminopyridine in 15 mL of dichloromethane, cooled to about 0° C., are added portionwise 2.84 g (14.07 mmol) of 4-nitrophenyl chloroformate. The medium is kept stirring at 0° C. for 1 hour and then at room temperature for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08697883B2 |
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| Source dataset | uspto-grants-2014_04 |
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| ORD ID | ord-093e125487994bdaa00133555a25b402 |
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| Source note | uspto-grants-2014_04 |
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