Hydrochloric Acid → HCID 178420117, compound

HRID 2367352Notes

Reaction equation

HRID 2367352 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH:12]3[O:17][CH2:16][CH2:15][N:14](CC4C=CC=CC=4)[CH2:13]3)[NH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:25]>[Pd].CO>[ClH:25].[C:1]1([C:7]2[N:8]=[C:9]([CH:12]3[O:17][CH2:16][CH2:15][NH:14][CH2:13]3)[NH:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 1784203192-(4-Phenyl-1H-imidazol-2-yl)-4-(phenylmethyl)morpholine

Product 2

HCID 313Hydrochloric AcidHCID 178420117HCID 178420117, compoundYield 92.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

Palladium on carbon (10 wt %, 300 mg, 0.282 mmol) was added to a solution of 2-(4-phenyl-1H-imidazol-2-yl)-4-(phenylmethyl)morpholine (900 mg, 2.82 mmol) and 36% aqueous HCl (0.713 mL, 8.45 mmol) in CH3OH (50 mL) under nitrogen, and the reaction mixture was stirred under hydrogen at 25° C. for 1.5 hours. The mixture was filtered, washed by methanol (150 mL), and concentrated to afford an HCl salt of the title compound (600 mg) as a brown solid. LC-MS (ES) m/z=230 [M+H]+.

Workup

  1. filtrationThe mixture was filtered
  2. washwashed by methanol (150 mL)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-5db12f4c0c644efbbd8ce1c5d222a09d
Source dataset
uspto-grants-2014_04
Patent number
US08697685B2

Reaction notes

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