Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

2-[4-(Phenylmethyl)-2-morpholinyl]-1H-imidazo[4,5-c]pyridine (1.0 g, 3.40 mmol) was hydrogenated in ethanol (30 mL) in the presence of Pd/C (10 wt %, 0.362 g, 0.340 mmol) and 0.2 mL of concentrated hydrochloric acid. After stirring at room temperature overnight, the catalyst was filtered off. The filtrate was concentrated to afford an HCl salt of the title compound (0.8 g) as a yellow oil. LC-MS (ES) m/z=205 [M+H]+.

Provenance & Evidence