Hydrochloric Acid → Hydrochloric Acid

HRID 2367377Notes

Reaction equation

HRID 2367377 reaction equation
C1(C[N:8]2[CH2:13][CH2:12][O:11][CH:10]([C:14]3[NH:15][C:16]4[CH:21]=[CH:20][N:19]=[CH:18][C:17]=4[N:22]=3)[CH2:9]2)C=CC=CC=1.[ClH:23]>C(O)C.[Pd]>[ClH:23].[NH:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]2[NH:15][C:16]3[CH:21]=[CH:20][N:19]=[CH:18][C:17]=3[N:22]=2)[CH2:9]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 178420318HCID 178420318, compound

Product 2

HCID 313Hydrochloric AcidHCID 178419858HCID 178419858, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-[4-(Phenylmethyl)-2-morpholinyl]-1H-imidazo[4,5-c]pyridine (1.0 g, 3.40 mmol) was hydrogenated in ethanol (30 mL) in the presence of Pd/C (10 wt %, 0.362 g, 0.340 mmol) and 0.2 mL of concentrated hydrochloric acid. After stirring at room temperature overnight, the catalyst was filtered off. The filtrate was concentrated to afford an HCl salt of the title compound (0.8 g) as a yellow oil. LC-MS (ES) m/z=205 [M+H]+.

Workup

  1. filtrationthe catalyst was filtered off
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-6ef3962f5634443fad5a15d9e5cdf5c2
Source dataset
uspto-grants-2014_04
Patent number
US08697685B2

Reaction notes

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