Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl{(3S,6R)-1-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate (985 mg, 2.310 mmol) in 1,4-dioxane (5 mL) was added 4M HCl in 1,4-dioxane (10 mL, 40.0 mmol) into a 40 mL vial. A solid formed, and the mixture was stirred at room temperature for 30 minutes, then concentrated to afford an HCl salt of the title compound (1.15 g) as a white solid. LC-MS (ES) m/z=327 [M+H]+.

Provenance & Evidence