Hydrochloric Acid → Hydrochloric Acid

HRID 2367420Notes

Reaction equation

HRID 2367420 reaction equation
CC([N:5]([C@H:9]1[CH2:14][CH2:13][C@@H:12]([CH3:15])[N:11]([C:16]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[C:24]([F:30])[CH:23]=3)[N:19]=[C:18]([NH2:31])[N:17]=2)[CH2:10]1)C(=O)[O-])(C)C.[ClH:32]>O1CCOCC1>[ClH:32].[NH2:31][C:18]1[N:19]=[C:20]([C:22]2[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[C:24]([F:30])[CH:23]=2)[CH:21]=[C:16]([N:11]2[CH2:10][C@@H:9]([NH2:5])[CH2:14][CH2:13][C@H:12]2[CH3:15])[N:17]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86659190HCID 86659190, compound

Product 2

HCID 313Hydrochloric AcidHCID 58504797HCID 58504797, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 1,1-dimethylethyl{(3S,6R)-1-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate (985 mg, 2.310 mmol) in 1,4-dioxane (5 mL) was added 4M HCl in 1,4-dioxane (10 mL, 40.0 mmol) into a 40 mL vial. A solid formed, and the mixture was stirred at room temperature for 30 minutes, then concentrated to afford an HCl salt of the title compound (1.15 g) as a white solid. LC-MS (ES) m/z=327 [M+H]+.

Workup

  1. customA solid formed
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-79ce051b7237485398c49e2d078e7de1
Source dataset
uspto-grants-2014_04
Patent number
US08697685B2

Reaction notes

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