反应详情

A mixture of 52 parts of 2-bromopropane, 19 parts of N-(4-piperidinyl)-3-pyridinamine, 33.3 parts of sodium carbonate, 3 parts of potassium iodide and 720 parts of 4-methyl-2-pentanone is stirred and refluxed for 24 hours. The reaction mixture is cooled and filtered. The filtrate is evaporated. The residue is purified by column-chromatography over silica gel using methanol as eluent. The pure fractions are collected and the eluent is evaporated. The residue is crystallized from 2,2'-oxybispropane, yielding 1.5 parts of N-[1-(1-methylethyl)-4-piperidinyl]-3-pyridinamine; mp. 100.7° C.

1. temperaturerefluxed for 24 hours
2. temperatureThe reaction mixture is cooled
3. filtrationfiltered
4. customThe filtrate is evaporated
5. customThe residue is purified by column-chromatography over silica gel
6. customThe pure fractions are collected
7. customthe eluent is evaporated
8. customThe residue is crystallized from 2,2'-oxybispropane