Hydrochloric Acid → Hydrochloric Acid

HRID 2367553Notes

Reaction equation

HRID 2367553 reaction equation
[CH2:1]([C@H:3]1[N:8](C(OC(C)(C)C)=O)[CH2:7][C@@H:6]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:17])[O:5][CH2:4]1)[CH3:2].O1CCOCC1.[ClH:31]>>[ClH:31].[CH2:1]([C@H:3]1[NH:8][CH2:7][C@@H:6]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:17])[O:5][CH2:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 51354039HCID 51354039, compound

Product 2

HCID 313Hydrochloric AcidHCID 51353731HCID 51353731, compound

Procedure

1,1-Dimethylethyl(2S,5R)-5-ethyl-2-[(phenylamino)carbonyl]-4-morpholinecarboxylate (0.269 g, 0.804 mmol) was taken up in HCl in 1,4-dioxane (4 M, 0.024 mL, 0.804 mmol) and stirred at room temperature overnight. The reaction was concentrated to yield a HCl salt of the title compound (0.198 g) as a brown oil. LC-MS (ES) m/z=235 [M+H]+.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-aeec427d47a54a6b880e3bed1a479ad3
Source dataset
uspto-grants-2014_04
Patent number
US08697685B2

Reaction notes

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