Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To 1,1-dimethylethyl{(3R)-1-[6-(4-cyano-3-fluorophenyl)-2-(methylamino)-4-pyrimidinyl]-3-piperidinyl}carbamate (0.544 g, 1.28 mmol) was added HCl in dioxane (4 mL, 16.00 mmol) at room temperature with stirring. A precipitate immediately formed. The mixture was stirred at room temperature overnight, and then concentrated to dryness to afford an HCl salt of the title compound (0.539 g) as an off-white solid. LC-MS (ES) m/z=327 [M+H]+.

Provenance & Evidence