Hydrochloric Acid → Hydrochloric Acid

HRID 2367617Notes

Reaction equation

HRID 2367617 reaction equation
CC([N:5]([C@@H:9]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[C:23]([F:29])[CH:22]=3)[N:18]=[C:17]([NH:30][CH3:31])[N:16]=2)[CH2:10]1)C(=O)[O-])(C)C.[ClH:32].O1CCOCC1>>[ClH:32].[NH2:5][C@@H:9]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:16]=[C:17]([NH:30][CH3:31])[N:18]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[C:23]([F:29])[CH:22]=3)[CH:20]=2)[CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86659200HCID 86659200, compound

Product 2

HCID 313Hydrochloric AcidHCID 58504604HCID 58504604, compound

Procedure

To 1,1-dimethylethyl{(3R)-1-[6-(4-cyano-3-fluorophenyl)-2-(methylamino)-4-pyrimidinyl]-3-piperidinyl}carbamate (0.544 g, 1.28 mmol) was added HCl in dioxane (4 mL, 16.00 mmol) at room temperature with stirring. A precipitate immediately formed. The mixture was stirred at room temperature overnight, and then concentrated to dryness to afford an HCl salt of the title compound (0.539 g) as an off-white solid. LC-MS (ES) m/z=327 [M+H]+.

Workup

  1. customA precipitate immediately formed
  2. stirringThe mixture was stirred at room temperature overnight
  3. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-cbea1d14975849edba248508396016f6
Source dataset
uspto-grants-2014_04
Patent number
US08697685B2

Reaction notes

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