Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To 1,1-dimethylethyl{(3R)-1-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-3-piperidinyl}carbamate (1.02 g, 2.473 mmol) was added 4M HCl in 1,4-dioxane (6.18 mL, 24.73 mmol), and the resulting mixture was stirred at room temperature for 1.5 hours. The reaction was then concentrated to afford an HCl salt of the title compound (1.03 g) as a yellow solid. LC-MS (ES) m/z=313 [M+H]+.

Provenance & Evidence