Hydrochloric Acid → Hydrochloric Acid

HRID 2367620Notes

Reaction equation

HRID 2367620 reaction equation
CC([N:5]([C@@H:9]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[C:23]([F:29])[CH:22]=3)[N:18]=[C:17]([NH2:30])[N:16]=2)[CH2:10]1)C(=O)[O-])(C)C.[ClH:31].O1CCOCC1>>[ClH:31].[NH2:30][C:17]1[N:18]=[C:19]([C:21]2[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[C:23]([F:29])[CH:22]=2)[CH:20]=[C:15]([N:11]2[CH2:12][CH2:13][CH2:14][C@@H:9]([NH2:5])[CH2:10]2)[N:16]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86659199HCID 86659199, compound

Product 2

HCID 313Hydrochloric AcidHCID 58504655HCID 58504655, compound

Procedure

To 1,1-dimethylethyl{(3R)-1-[2-amino-6-(4-cyano-3-fluorophenyl)-4-pyrimidinyl]-3-piperidinyl}carbamate (1.02 g, 2.473 mmol) was added 4M HCl in 1,4-dioxane (6.18 mL, 24.73 mmol), and the resulting mixture was stirred at room temperature for 1.5 hours. The reaction was then concentrated to afford an HCl salt of the title compound (1.03 g) as a yellow solid. LC-MS (ES) m/z=313 [M+H]+.

Workup

  1. concentrationThe reaction was then concentrated

Sources & evidence

ORD record
ord-f6c901f36c334b7d9356b9434060f0e6
Source dataset
uspto-grants-2014_04
Patent number
US08697685B2

Reaction notes

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