Ammonia → HCID 15700627, compound

HRID 236781Notes

Reaction equation

HRID 236781 reaction equation
[CH:1]([NH:3][C:4]1[C:5]2[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=2[S:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:2].Cl.N.[CH2:21]1CCCCC1>O.C(Cl)Cl>[C:1]([NH:3][C:4]1[C:5]2[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=2[S:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:2])[CH3:21]

Participants

7

Reactant 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 8078CyclohexaneHCID 157006253-Formamido-2-phenyl-benzo(b)thiophene

Product 1

HCID 15700627HCID 15700627, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

67.0 g (0.265 mol) of 3-formamido-2-phenyl-benzo(b)thiophene and 700 milliliters of HCl at 25% are refluxed with stirring for 8 hours. After cooling, it is diluted with water, neutralised by ammonia and the product is dissolved in CH2Cl2. By evaporating the organic phase dried over K2CO3, 58.7 g (98% of theory) of 2-phenyl-3-amino-benzo-(b)thiophene are obtained; yellow plates melting between 110° and 112° C. (cyclohexane).

Workup

  1. temperatureAfter cooling
  2. customBy evaporating the organic phase
  3. dry with materialdried over K2CO3, 58.7 g (98% of theory) of 2-phenyl-3-amino-benzo-(b)thiophene
  4. customare obtained
  5. custommelting between 110° and 112° C.

Sources & evidence

ORD record
ord-cfd4f86d07494e81a34f7b9397722571
Source dataset
uspto-grants-1979_06
Patent number
US04157399

Reaction notes

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