HCID 67342250, compound → HCID 70655230, compound

HRID 2368040Notes

Reaction equation

HRID 2368040 reaction equation
[F:1][C:2]([F:20])([F:19])[CH:3]1[CH2:8][CH2:7][C:6]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH2:18])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)=[CH:5][CH2:4]1>CO.[Pd]>[F:20][C:2]([F:1])([F:19])[CH:3]1[CH2:4][CH2:5][CH:6]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH2:18])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:7][CH2:8]1

Participants

4

Reactant 1

HCID 67342250HCID 67342250, compound

Product 1

HCID 70655230HCID 70655230, compoundYield 99.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

To a solution 8-(4-trifluoromethyl-cyclohexenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-ylamine (CAS 1329673-42-8, US 20110201605) (30 mg, 0.106 mmol) in methanol (5 mL) was added 10% Pd/C (30 mg), and the reaction mixture was allowed to stir at 25° C. for 2 hours under hydrogen balloon atmosphere. The reaction mixture was filtered through a bed of celite and the filtrate was evaporated off in vacuo yield the title compound as a white solid (30 mg, 99%) which was used in the next step without further purification. MS ISP (m/e): 285.2 (100) [(M+H)+].

Workup

  1. filtrationThe reaction mixture was filtered through a bed of celite
  2. customthe filtrate was evaporated off in vacuo

Sources & evidence

ORD record
ord-d98a2ece73ec4429ac1409b3029f2ede
Source dataset
uspto-grants-2014_04
Patent number
US08703763B2

Reaction notes

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