4-Bromo-1-methylpyridin-2(1H)-one → HCID 68759408, compound

HRID 2368048Notes

Reaction equation

[CH:1]1([CH:4]([C:23]2[CH:28]=[CH:27][C:26](B3OC(C)(C)C(C)(C)O3)=[CH:25][CH:24]=2)[N:5]2[CH2:10][CH2:9][C:8]([CH2:17][C:18]([OH:21])([CH3:20])[CH3:19])([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:7][C:6]2=[O:22])[CH2:3][CH2:2]1.Br[C:39]1[CH:44]=[CH:43][N:42]([CH3:45])[C:41](=[O:46])[CH:40]=1>>[CH:1]1([CH:4]([C:23]2[CH:28]=[CH:27][C:26]([C:39]3[CH:44]=[CH:43][N:42]([CH3:45])[C:41](=[O:46])[CH:40]=3)=[CH:25][CH:24]=2)[N:5]2[CH2:10][CH2:9][C:8]([CH2:17][C:18]([OH:21])([CH3:20])[CH3:19])([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:7][C:6]2=[O:22])[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 221323964-Bromo-1-methylpyridin-2(1H)-one

HCID 68758548HCID 68758548, compound

Product 1

HCID 68759408HCID 68759408, compound

Procedure

The title compound was prepared from 3-{cyclopropyl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]methyl}-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one (for preparation see below) and 4-bromo-1-methyl-1H-pyridin-2-one following a procedure analogous to that described in Example 3. LC-MS (Method 1): tR=3.57 min; Mass spectrum (ESI+): m/z=487 [M+H]+.

Sources & evidence

ORD record: ord-2d65dd8502d44cdcba8ad0150ad10aba
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08703765B2

Reaction notes

Loading…