5-Bromo-1-methylpyridin-2(1H)-one → HCID 68759699, compound

HRID 2368049Notes

Reaction equation

[CH:1]1([CH:4]([C:23]2[CH:28]=[CH:27][C:26](C3C=CN(C)C(=O)C=3)=[CH:25][CH:24]=2)[N:5]2[CH2:10][CH2:9][C:8]([CH2:17][C:18]([OH:21])([CH3:20])[CH3:19])([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:7][C:6]2=[O:22])[CH2:3][CH2:2]1.Br[C:38]1[CH:39]=[CH:40][C:41](=[O:45])[N:42]([CH3:44])[CH:43]=1>>[CH:1]1([CH:4]([C:23]2[CH:28]=[CH:27][C:26]([C:38]3[CH:39]=[CH:40][C:41](=[O:45])[N:42]([CH3:44])[CH:43]=3)=[CH:25][CH:24]=2)[N:5]2[CH2:10][CH2:9][C:8]([CH2:17][C:18]([OH:21])([CH3:19])[CH3:20])([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:7][C:6]2=[O:22])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 130240275-Bromo-1-methylpyridin-2(1H)-one

HCID 68759408HCID 68759408, compound

Product 1

HCID 68759699HCID 68759699, compound

Procedure

The title compound was prepared from 3-{cyclopropyl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]methyl}-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one (for preparation see Example 3) and 5-bromo-1-methyl-1H-pyridin-2-one following a procedure analogous to that described in Example 3. LC-MS (Method 1): tR=3.34 min; Mass spectrum (ESI+): m/z=487 [M+H]+.

Sources & evidence

ORD record: ord-85fc93f6c97340e482513021c86279b9
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08703765B2

Reaction notes

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