1-(2-Hydroxyethyl)piperazine → HCID 12703405, compound

HRID 236808Notes

Reaction equation

HRID 236808 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8](Cl)=[N:7][C:6]=2[CH:16]=1.[OH:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30]>C1(C)C=CC=CC=1>[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3=[CH:12][S:13][CH:14]=[C:9]3[C:8]([N:23]3[CH2:24][CH2:25][N:20]([CH2:19][CH2:18][OH:17])[CH2:21][CH2:22]3)=[N:7][C:6]=2[CH:16]=1

Participants

5

Reactant 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 444972Fumaric AcidHCID 21315986HCID 21315986, compound

Product 1

HCID 12703405HCID 12703405, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-Methyl-10-chloro-thieno[3,4-b][1,5]benzoxazepine (Example 7) is reacted with 20 ml. of N-(2-hydroxyethyl)-piperazine in 20 ml. of dry toluene as described in Example 1, giving the base compound which is further reacted with fumaric acid, giving the desired product as the fumarate salt, m.p. 178°-180° C.

Workup

  1. customgiving the base compound which

Sources & evidence

ORD record
ord-1c48e5666c8942a78df5a72803bc85e1
Source dataset
uspto-grants-1979_06
Patent number
US04157444

Reaction notes

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