Hydrogen chloride-ethyl acetate → HCID 67449164, compound

HRID 2368083Notes

Reaction equation

HRID 2368083 reaction equation
[C:1]([NH:4][CH:5]([CH3:21])[CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)(=[O:3])[CH3:2].[ClH:22].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:22].[CH3:21][CH:5]([NH:4][C:1](=[O:3])[CH3:2])[CH2:6][CH2:7][CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67447123HCID 67447123, compound

Product 1

HCID 67449164HCID 67449164, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl 4-[3-(acetylamino)butyl]piperidine-1-carboxylate (2.65 g) in ethyl acetate (30 mL) was added 4 M hydrogen chloride/ethyl acetate (10 mL), and the mixture was stirred at room temperature for 3 hr. The resulting precipitate was collected by filtration to give the title compound (2.06 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-0581df7d97994bf98d75189e57ceff52
Source dataset
uspto-grants-2014_04
Patent number
US08703758B2

Reaction notes

Loading…