反应详情

温度

120 °C

A mixture of benzyl 4-(oxiran-2-ylmethoxy)piperidine-1-carboxylate (1.81 g) and tetrabutylammonium dihydrogen trifluoride (3.74 g) was stirred at 120° C. overnight. The reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (960 mg).

1. customThe reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane)