HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2368106Generated: November 2, 2026
N,N,N-Tributylbutan-1-aminium fluoride--hydrogen fluoride (1/1/2) → Benzyl 4-(3-fluoro-2-hydroxypropoxy)piperidine-1-carboxylate
https://huagongshe.com/reaction/2368106
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,N,N-Tributylbutan-1-aminium fluoride--hydrogen fluoride (1/1/2) | HCID 11748636 | — |
| Reactant | Benzyl 4-(oxiran-2-ylmethoxy)piperidine-1-carboxylate | HCID 57517497 | — |
| Product | Benzyl 4-(3-fluoro-2-hydroxypropoxy)piperidine-1-carboxylate | HCID 67449609 | 49.6% |
Reaction Steps
A mixture of benzyl 4-(oxiran-2-ylmethoxy)piperidine-1-carboxylate (1.81 g) and tetrabutylammonium dihydrogen trifluoride (3.74 g) was stirred at 120° C. overnight. The reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (960 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08703758B2 |
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| Source dataset | uspto-grants-2014_04 |
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| ORD ID | ord-023ef5c070954373bd9b5b3363bd4a00 |
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| Source note | uspto-grants-2014_04 |
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