HCID 67447624, compound → HCID 86658703, compound

HRID 2368109Notes

Reaction equation

HRID 2368109 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH3:28])[CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][N:15](C(OCC2C=CC=CC=2)=O)[CH2:14][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[C].[Pd]>[CH3:28][C@H:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

Participants

4

Reactant 1

HCID 67447624HCID 67447624, compound

Product 1

HCID 86658703HCID 86658703, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of benzyl 4-{(3S)-3-[(tert-butoxycarbonyl)amino]butyl}piperazine-1-carboxylate (1.10 g) in ethanol (10 mL) was added 10% palladium carbon (1.50 g), and the mixture was stirred at room temperature for 30 min under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was evaporated under reduced pressure to give tert-butyl [(1S)-1-methyl-3-(piperazin-1-yl)propyl]carbamate. By a method similar to Example 1, steps F to H, and using the obtained compound, the title compound was obtained.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-736b5277df89418780373ce38d50d8b8
Source dataset
uspto-grants-2014_04
Patent number
US08703758B2

Reaction notes

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