HCID 67447624, compound → HCID 86658703, compound

Participants

Reaction Steps

To a solution of benzyl 4-{(3S)-3-[(tert-butoxycarbonyl)amino]butyl}piperazine-1-carboxylate (1.10 g) in ethanol (10 mL) was added 10% palladium carbon (1.50 g), and the mixture was stirred at room temperature for 30 min under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was evaporated under reduced pressure to give tert-butyl [(1S)-1-methyl-3-(piperazin-1-yl)propyl]carbamate. By a method similar to Example 1, steps F to H, and using the obtained compound, the title compound was obtained.

Provenance & Evidence