Sulfuryl chloride → HCID 12581868, compound

HRID 236812Notes

Reaction equation

HRID 236812 reaction equation
[CH:1]1[S:2][CH:3]=[C:4]2[C:10]=1[C:9](=[O:11])[NH:8][C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[O:5]2.S(Cl)([Cl:19])(=O)=O>C(Cl)Cl>[Cl:19][C:3]1[S:2][CH:1]=[C:10]2[C:9](=[O:11])[NH:8][C:7]3[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=3[O:5][C:4]=12

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 12581860HCID 12581860, compound

Product 1

HCID 12581868HCID 12581868, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

An 8.0 g. portion of thieno[3,4-b][1,5]benzoxazepin-10(9H)-one is suspended in 364 ml. of methylene chloride. A 3.27 ml. portion of sulfuryl chloride is added dropwise and the mixture is stirred overnight. The solid is collected and washed with methylene chloride, giving 3-chloro-thieno[3,4-b][1,5]benzoxazepin-10(9H)-one.

Workup

  1. customThe solid is collected
  2. washwashed with methylene chloride

Sources & evidence

ORD record
ord-01e344525ecb49d88c449d4a323f91d4
Source dataset
uspto-grants-1979_06
Patent number
US04157444

Reaction notes

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