HCID 57517503, compound → 4-(Cyclopropylmethoxy)-3-fluorobenzenamine

HRID 2368123Notes

Reaction equation

HRID 2368123 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][C:7]=2[F:15])[CH2:3][CH2:2]1>CO.[C].[Pd]>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:7]=2[F:15])[CH2:2][CH2:3]1

Participants

4

Reactant 1

HCID 57517503HCID 57517503, compound

Product 1

HCID 196272444-(Cyclopropylmethoxy)-3-fluorobenzenamineYield 96.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A suspension of 1-(cyclopropylmethoxy)-2-fluoro-4-nitrobenzene (18.3 g) and 5% palladium carbon (containing water (50%), 1.84 g) in methanol (289 mL) was stirred for 3 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (15.2 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-2bc80886d5f54fa9af817617c089e82f
Source dataset
uspto-grants-2014_04
Patent number
US08703758B2

Reaction notes

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