反应详情

温度

0 °C

To a solution of 4-[({trans-4-[6-(cyclopropylmethoxy)-1-benzofuran-2-yl]cyclohexyl}oxy)acetyl]morpholine (881 mg) in THF (10 mL) was added a solution (1.5 M, 2.84 mL) of methylmagnesium bromide in toluene/THF under ice-cooling. The mixture was stirred at 0° C. for 1 hr and extracted with ethyl acetate and 1M hydrochloric acid. The obtained organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (556 mg).

1. temperaturecooling
2. extractionextracted with ethyl acetate and 1M hydrochloric acid
3. washThe obtained organic layer was washed with saturated brine
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe obtained residue was purified by silica gel chromatography (hexane/ethyl acetate)