反应详情

A mixture of 4-({(2S)-2-[(tert-butoxycarbonyl)amino]propyl}oxy)phenyl acetate (70 g), potassium carbonate (156 g) and methanol (800 mL) was stirred at room temperature for 3 days. The reaction mixture was concentrated under reduced pressure, and the obtained residue was neutralized with aqueous citric acid solution, and diluted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (40.5 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additiondiluted with ethyl acetate
3. washThe organic layer was washed with saturated brine
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was evaporated under reduced pressure