反应详情

温度

60 °C

A suspension of tert-butyl [(1S)-2-(4-hydroxyphenoxy)-1-methylethyl]carbamate (40 g) and 5% rhodium-carbon (containing water (50%), 8.0 g) in methanol (600 mL) was stirred at 60° C. for 3 hr under a hydrogen atmosphere (5 atm). The catalyst was removed by filtration, and the filtrate was concentrated. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (8.3 g).

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by silica gel chromatography (hexane/ethyl acetate)