HCID 86658713, compound → HCID 178461792, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of tert-butyl [(1S)-2-(4-hydroxyphenoxy)-1-methylethyl]carbamate (40 g) and 5% rhodium-carbon (containing water (50%), 8.0 g) in methanol (600 mL) was stirred at 60° C. for 3 hr under a hydrogen atmosphere (5 atm). The catalyst was removed by filtration, and the filtrate was concentrated. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (8.3 g).

Provenance & Evidence