Morpholine → HCID 86662437, compound

HRID 2368169Notes

Reaction equation

Cl[C:2]1[N:3]=[N:4][C:5]([Cl:22])=[CH:6][C:7]=1[C:8]([NH:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=1)=[O:9].[NH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>C(Cl)(Cl)Cl>[Cl:22][C:5]1[N:4]=[N:3][C:2]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[C:7]([C:8]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)=[O:9])[CH:6]=1

Participants

Conditions

Temperature: 25 °C

Procedure

To a solution of 3,6-dichloro-N-(3,4-dimethoxybenzyl)pyridazine-4-carboxamide (1-2, 0.100 g, 0.292 mmol, 1.0 equiv) in chloroform (0.97 mL) at 25° C. was added morpholine (0.0252 g, 0.292 mmol, 1.0 equiv) and the reaction mixture was stirred for 24 hours at 25° C. The reaction mixture was directly purified by normal phase column chromatography (15 to 100% EtOAc in hexanes) to give the product as a yellow solid. ESI+MS [M+H]+ C18H21ClN4O4: 393.2 found, 393.1 required.

Workup

customThe reaction mixture was directly purified by normal phase column chromatography (15 to 100% EtOAc in hexanes)

Sources & evidence

ORD record: ord-32699032d1ad49ffb3a058d9f78e1fae
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08703770B2

Reaction notes

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