Morpholine → HCID 86662437, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3,6-dichloro-N-(3,4-dimethoxybenzyl)pyridazine-4-carboxamide (1-2, 0.100 g, 0.292 mmol, 1.0 equiv) in chloroform (0.97 mL) at 25° C. was added morpholine (0.0252 g, 0.292 mmol, 1.0 equiv) and the reaction mixture was stirred for 24 hours at 25° C. The reaction mixture was directly purified by normal phase column chromatography (15 to 100% EtOAc in hexanes) to give the product as a yellow solid. ESI+MS [M+H]+ C18H21ClN4O4: 393.2 found, 393.1 required.

Provenance & Evidence