HCID 67152964, compound → HCID 67153036, compound

HRID 2368203Notes

Reaction equation

HRID 2368203 reaction equation
C([O:5][C:6](=[O:38])[CH:7]([NH:9][C:10](=[O:37])[CH:11]([CH2:29][C:30]1[CH:35]=[CH:34][C:33]([Br:36])=[CH:32][CH:31]=1)[CH2:12][P:13]([CH:16]([NH:18]C(OCC1C=CC=CC=1)=O)[CH3:17])([OH:15])=[O:14])[CH3:8])(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:18][CH:16]([P:13]([OH:15])([CH2:12][CH:11]([CH2:29][C:30]1[CH:35]=[CH:34][C:33]([Br:36])=[CH:32][CH:31]=1)[C:10]([NH:9][CH:7]([CH3:8])[C:6]([OH:38])=[O:5])=[O:37])=[O:14])[CH3:17]

Participants

3

Reactant 1

HCID 67152964HCID 67152964, compound

Product 1

HCID 67153036HCID 67153036, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

The compound obtained in step 2 is solubilised in a 50:50 CH2Cl2/TFA mixture (40 ml) and the mixture is stirred for 1 hour at ambient temperature. The residue is evaporated to dryness, taken up with water and freeze-dried. 1.0 g of the expected compound is obtained.

Workup

  1. customThe residue is evaporated to dryness
  2. customfreeze-dried

Sources & evidence

ORD record
ord-8395305c56ee4fd181789dfc1b4dea30
Source dataset
uspto-grants-2014_04
Patent number
US08703747B2

Reaction notes

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