Methoxyisopropylamine → HCID 58548383, compound

HRID 2368260Notes

Reaction equation

[CH3:1][O:2][CH2:3][CH:4]([NH2:6])[CH3:5].C[O:8][C:9]([C:11]1[C:15]([NH:16][C:17]([C:19]2[C:24]([NH:25][C:26]3[CH:27]=[N:28][CH:29]=[N:30][CH:31]=3)=[CH:23][CH:22]=[C:21]([CH:32]3[CH2:34][CH2:33]3)[N:20]=2)=[O:18])=[CH:14][N:13]([CH3:35])[N:12]=1)=O>>[CH3:1][O:2][CH2:3][CH:4]([NH:6][C:9]([C:11]1[C:15]([NH:16][C:17]([C:19]2[C:24]([NH:25][C:26]3[CH:27]=[N:28][CH:29]=[N:30][CH:31]=3)=[CH:23][CH:22]=[C:21]([CH:32]3[CH2:34][CH2:33]3)[N:20]=2)=[O:18])=[CH:14][N:13]([CH3:35])[N:12]=1)=[O:8])[CH3:5]

Participants

Reactant 2

HCID 123458Methoxyisopropylamine

HCID 700992004-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

Product 1

HCID 58548383HCID 58548383, compoundYield 16%

Procedure

According to the general method described in step 5 of example 27, reaction of 2-methoxy-1-methyl-ethylamine with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (16%) as amorphous yellow solid.

Sources & evidence

ORD record: ord-7b7831ff20ee4fa69fb23d78e48b37b8
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08703768B2

Reaction notes

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