3-Amino-1,2-propanediol → HCID 58548392, compound

HRID 2368261Notes

Reaction equation

HRID 2368261 reaction equation
[NH2:1][CH2:2][CH:3]([OH:6])[CH2:4][OH:5].C[O:8][C:9]([C:11]1[C:15]([NH:16][C:17]([C:19]2[C:24]([NH:25][C:26]3[CH:27]=[N:28][CH:29]=[N:30][CH:31]=3)=[CH:23][CH:22]=[C:21]([CH:32]3[CH2:34][CH2:33]3)[N:20]=2)=[O:18])=[CH:14][N:13]([CH3:35])[N:12]=1)=O>>[OH:6][CH:3]([CH2:4][OH:5])[CH2:2][NH:1][C:9]([C:11]1[C:15]([NH:16][C:17]([C:19]2[C:24]([NH:25][C:26]3[CH:27]=[N:28][CH:29]=[N:30][CH:31]=3)=[CH:23][CH:22]=[C:21]([CH:32]3[CH2:34][CH2:33]3)[N:20]=2)=[O:18])=[CH:14][N:13]([CH3:35])[N:12]=1)=[O:8]

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 700992004-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

Product 1

HCID 58548392HCID 58548392, compoundYield 15%

Procedure

According to the general method described in step 5 of example 27, reaction of 3-amino-propane-1,2-diol with 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester provided the title compound (15%) as sticky solid.

Sources & evidence

ORD record
ord-044ede6f51314d0c9e6d0776c5da3667
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

Loading…