3-Amino-1,2-propanediol → HCID 70098408, compound

HRID 2368296Notes

Reaction equation

HRID 2368296 reaction equation
[NH2:1][CH2:2][CH:3]([OH:6])[CH2:4][OH:5].[CH:7]1([C:10]2[N:15]=[C:14]([C:16]([NH:18][C:19]3[CH:27]=[N:26][CH:25]=[CH:24][C:20]=3[C:21](O)=[O:22])=[O:17])[C:13]([NH:28][C:29]3[CH:30]=[N:31][CH:32]=[N:33][CH:34]=3)=[CH:12][CH:11]=2)[CH2:9][CH2:8]1>>[OH:6][CH:3]([CH2:4][OH:5])[CH2:2][NH:1][C:21]([C:20]1[CH:24]=[CH:25][N:26]=[CH:27][C:19]=1[NH:18][C:16]([C:14]1[C:13]([NH:28][C:29]2[CH:30]=[N:31][CH:32]=[N:33][CH:34]=2)=[CH:12][CH:11]=[C:10]([CH:7]2[CH2:9][CH2:8]2)[N:15]=1)=[O:17])=[O:22]

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 70098408HCID 70098408, compoundYield 33%

Procedure

According to the general method described in step 3 of example 53, reaction of 3-amino-propan-1,2-diol with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (33%) as amorphous yellow solid.

Sources & evidence

ORD record
ord-58553d9bec394703a58a0787331219c0
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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