3,3-Difluoroazetidine → HCID 70116466, compound

HRID 2368305Notes

Reaction equation

HRID 2368305 reaction equation
[F:1][C:2]1([F:6])[CH2:5][NH:4][CH2:3]1.[CH:7]1([C:10]2[N:15]=[C:14]([C:16]([NH:18][C:19]3[CH:27]=[N:26][CH:25]=[CH:24][C:20]=3[C:21](O)=[O:22])=[O:17])[C:13]([NH:28][C:29]3[CH:30]=[N:31][CH:32]=[N:33][CH:34]=3)=[CH:12][CH:11]=2)[CH2:9][CH2:8]1>>[F:1][C:2]1([F:6])[CH2:5][N:4]([C:21]([C:20]2[CH:24]=[CH:25][N:26]=[CH:27][C:19]=2[NH:18][C:16]([C:14]2[C:13]([NH:28][C:29]3[CH:30]=[N:31][CH:32]=[N:33][CH:34]=3)=[CH:12][CH:11]=[C:10]([CH:7]3[CH2:9][CH2:8]3)[N:15]=2)=[O:17])=[O:22])[CH2:3]1

Participants

3

Reactant 2

HCID 27582483,3-DifluoroazetidineHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 70116466HCID 70116466, compoundYield 26%

Procedure

According to the general method described in step 3 of example 53, reaction of 3,3-difluoroazetidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound as yellow powder (26%).

Sources & evidence

ORD record
ord-bb4b314740fe4dd6a768814d812f5e77
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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