3-Hydroxyazetidine → HCID 58548390, compound

HRID 2368309Notes

Reaction equation

HRID 2368309 reaction equation
[OH:1][CH:2]1[CH2:5][NH:4][CH2:3]1.[CH:6]1([C:9]2[N:14]=[C:13]([C:15]([NH:17][C:18]3[CH:26]=[N:25][CH:24]=[CH:23][C:19]=3[C:20](O)=[O:21])=[O:16])[C:12]([NH:27][C:28]3[CH:29]=[N:30][CH:31]=[N:32][CH:33]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1>>[OH:1][CH:2]1[CH2:5][N:4]([C:20]([C:19]2[CH:23]=[CH:24][N:25]=[CH:26][C:18]=2[NH:17][C:15]([C:13]2[C:12]([NH:27][C:28]3[CH:29]=[N:30][CH:31]=[N:32][CH:33]=3)=[CH:11][CH:10]=[C:9]([CH:6]3[CH2:8][CH2:7]3)[N:14]=2)=[O:16])=[O:21])[CH2:3]1

Participants

3

Reactant 2

HCID 15142903-HydroxyazetidineHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Product 1

HCID 58548390HCID 58548390, compoundYield 8%

Procedure

According to the general method described in step 3 of example 53, reaction of 3-hydroxy-azetidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (8%) as light yellow powder.

Sources & evidence

ORD record
ord-1a4f107c685f444fb5095b6079fe0820
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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