2,2-Dimethylpyrrolidine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(2,2-dimethyl-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amide

HRID 2368310Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2368310
[CH3:1][C:2]1([CH3:7])[CH2:6][CH2:5][CH2:4][NH:3]1.[CH:8]1([C:11]2[N:16]=[C:15]([C:17]([NH:19][C:20]3[CH:28]=[N:27][CH:26]=[CH:25][C:21]=3[C:22](O)=[O:23])=[O:18])[C:14]([NH:29][C:30]3[CH:31]=[N:32][CH:33]=[N:34][CH:35]=3)=[CH:13][CH:12]=2)[CH2:10][CH2:9]1>>[CH3:1][C:2]1([CH3:7])[CH2:6][CH2:5][CH2:4][N:3]1[C:22]([C:21]1[CH:25]=[CH:26][N:27]=[CH:28][C:20]=1[NH:19][C:17]([C:15]1[C:14]([NH:29][C:30]2[CH:31]=[N:32][CH:33]=[N:34][CH:35]=2)=[CH:13][CH:12]=[C:11]([CH:8]2[CH2:10][CH2:9]2)[N:16]=1)=[O:18])=[O:23]

Komponenten

3

Edukt 2

HCID 4147732,2-DimethylpyrrolidineHCID 700980543-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid

Produkt 1

HCID 585482586-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(2,2-dimethyl-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amideAusbeute 23 %

Versuchsvorschrift

According to the general method described in step 3 of example 53, reaction of 2,2-dimethylpyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (23%) as sticky yellow solid.

Quellen und Nachweise

ORD-Eintrag
ord-a07524ed44b949859b247317524f69a2
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08703768B2

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