2,2-Dimethylpyrrolidine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(2,2-dimethyl-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2,2-Dimethylpyrrolidine	HCID 414773	—
Edukt	3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid	HCID 70098054	—
Produkt	6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [4-(2,2-dimethyl-pyrrolidine-1-carbonyl)-pyridin-3-yl]-amide	HCID 58548258	23%

Reaktionsschritte

According to the general method described in step 3 of example 53, reaction of 2,2-dimethylpyrrolidine with 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carbonyl]-amino}-isonicotinic acid provided the title compound (23%) as sticky yellow solid.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08703768B2
Quelldatensatz	uspto-grants-2014_04
ORD ID	ord-a07524ed44b949859b247317524f69a2
Quellennotiz	uspto-grants-2014_04