4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide → 6-Cyclopropyl-N-(1-methyl-5-(methylcarbamoyl)-1H-pyrazol-4-yl)-3-(pyrazin-2-ylamino)pyrazine-2-carboxamide

HRID 2368355Notes

Reaction equation

HRID 2368355 reaction equation
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([O:12]C)=O)[C:7]([NH:14][C:15]3[CH:20]=[N:19][CH:18]=[CH:17][N:16]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.[NH2:21][C:22]1[CH:23]=[N:24][N:25]([CH3:31])[C:26]=1[C:27]([NH:29][CH3:30])=[O:28]>>[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:21][C:22]3[CH:23]=[N:24][N:25]([CH3:31])[C:26]=3[C:27](=[O:28])[NH:29][CH3:30])=[O:12])[C:7]([NH:14][C:15]3[CH:20]=[N:19][CH:18]=[CH:17][N:16]=3)=[N:6][CH:5]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 64853704-amino-N,1-dimethyl-1H-pyrazole-5-carboxamideHCID 70098647Methyl 6-cyclopropyl-3-(pyrazin-2-ylamino)pyrazine-2-carboxylate

Product 1

HCID 547600216-Cyclopropyl-N-(1-methyl-5-(methylcarbamoyl)-1H-pyrazol-4-yl)-3-(pyrazin-2-ylamino)pyrazine-2-carboxamide

Procedure

According to the procedure described in step 2 of example 14, methyl 6-cyclopropyl-3-(pyrazin-2-ylamino)pyrazine-2-carboxylate was reacted with 4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide to give the title compound. Yellow solid.

Sources & evidence

ORD record
ord-77ce4dc97c7b4e78be2b73104b0e7949
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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