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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2368355Generated: October 30, 2026

4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide → 6-Cyclopropyl-N-(1-methyl-5-(methylcarbamoyl)-1H-pyrazol-4-yl)-3-(pyrazin-2-ylamino)pyrazine-2-carboxamide

https://huagongshe.com/reaction/2368355

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamideHCID 6485370—
ReactantMethyl 6-cyclopropyl-3-(pyrazin-2-ylamino)pyrazine-2-carboxylateHCID 70098647—
Product6-Cyclopropyl-N-(1-methyl-5-(methylcarbamoyl)-1H-pyrazol-4-yl)-3-(pyrazin-2-ylamino)pyrazine-2-carboxamideHCID 54760021—

Reaction Steps

According to the procedure described in step 2 of example 14, methyl 6-cyclopropyl-3-(pyrazin-2-ylamino)pyrazine-2-carboxylate was reacted with 4-amino-N,1-dimethyl-1H-pyrazole-5-carboxamide to give the title compound. Yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08703768B2
Source datasetuspto-grants-2014_04
ORD IDord-77ce4dc97c7b4e78be2b73104b0e7949
Source noteuspto-grants-2014_04