3-Bromopyridine → HCID 70095771, compound

HRID 2368360Notes

Reaction equation

HRID 2368360 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][CH:8]=[C:7]([CH:12]2[CH2:14][CH2:13]2)[N:6]=1)=[O:4].Br[C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1>>[CH3:1][O:2][C:3]([C:5]1[C:10]([NH:11][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:9][CH:8]=[C:7]([CH:12]2[CH2:14][CH2:13]2)[N:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 122863-BromopyridineHCID 67299911HCID 67299911, compound

Product 1

HCID 70095771HCID 70095771, compound

Procedure

The product was obtained starting from 3-amino-6-cyclopropylpyrazine-2-carboxylic acid methyl ester (200 mg, 1.04 mmol; intermediate A-10, step 2) and 3-bromopyridine (142 μl, 1.45 mmol) according to the method described in example A-1, step 2 as yellow solid (192 mg, 68%).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-06b1b751f4e6490eb8a677fb1a1a2cb0
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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