反应详情

To a solution of methyl 3-(bis(tert-butoxycarbonyl)amino)-6-bromopyrazine-2-carboxylate (500 mg, 1.16 mmol; example A-10, step 1) in MeOH (10 ml) was added sodium methoxide (30%; 280 μl, 1.5 mmol) at room temperature and stirring was continued at r.t. for 2 h. The reaction mixture was poured into ethyl acetate (75 ml) and extracted with potassium hydrogen sulfate (10%). The organic phase was washed with water and brine and the aqueous layers were back-extracted with ethyl acetate. The organic layers were dried and evaporated and the product was obtained after purification by silica gel chromatography using a heptane/ethyl acetate gradient as colorless solid (320 mg, 71%).

1. customat room temperature
2. extractionextracted with potassium hydrogen sulfate (10%)
3. washThe organic phase was washed with water and brine
4. extractionthe aqueous layers were back-extracted with ethyl acetate
5. customThe organic layers were dried
6. customevaporated
7. customthe product was obtained
8. customafter purification by silica gel chromatography