Lithium iodide → HCID 70099812, compound

HRID 2368377Notes

Reaction equation

HRID 2368377 reaction equation
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[C:18]([C:19]([O:21]C)=[O:20])=[C:17]([CH3:23])[C:16]([CH3:24])=[CH:15][CH:14]=3)=[O:11])[C:7]([NH:25][C:26]3[CH:27]=[N:28][CH:29]=[N:30][CH:31]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.[I-].[Li+]>N1C=CC=CC=1>[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[C:18]([C:19]([OH:21])=[O:20])=[C:17]([CH3:23])[C:16]([CH3:24])=[CH:15][CH:14]=3)=[O:11])[C:7]([NH:25][C:26]3[CH:27]=[N:28][CH:29]=[N:30][CH:31]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 66321Lithium iodideHCID 70097488HCID 70097488, compound

Product 1

HCID 70099812HCID 70099812, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of methyl 6-(6-cyclopropyl-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamido)-2,3-dimethylbenzoate (0.05 g, 119 μmol) in pyridine (1 ml) at r.t under an argon atmosphere was added lithium iodide (125 mg, 932 μmol). The mixture was heated at 100° for 16 hr. The solvent was evaporated. The crude product was used directly in the next step.

Workup

  1. temperatureThe mixture was heated at 100° for 16 hr
  2. customThe solvent was evaporated

Sources & evidence

ORD record
ord-edd1679404af4ff89e362890676a19d9
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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