Hydrochloric Acid → HCID 70099521, compound

HRID 2368392Notes

Reaction equation

HRID 2368392 reaction equation
[OH:1][C:2]([CH3:23])([CH3:22])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:19]([O-:21])=[O:20])=[C:9]([CH:18]=1)[C:10]([O:12]CC(O)(C)C)=[O:11].[OH-].[Na+].Cl>CO>[OH:1][C:2]([CH3:23])([CH3:22])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([N+:19]([O-:21])=[O:20])=[C:9]([CH:18]=1)[C:10]([OH:12])=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70098411HCID 70098411, compound

Product 1

HCID 70099521HCID 70099521, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-hydroxy-2-methylpropyl 5-(2-hydroxy-2-methylpropoxy)-2-nitrobenzoate (0.24 g, 733 μmol) in MeOH (10 ml) at r.t was added NaOH 1 N (2.2 ml, 2.2 mmol). The solution was stirred at r.t overnight. 2.2 ml 1 N HCl were added. The solvents were evaporated. The residue was dissolved in methylenechloride/MeOH 9:1 (100 ml), washed with 10 ml H2O, dried over MgSO4, filtered and evaporated to give the title compound (149 mg, 80%) as off-white solid.

Workup

  1. customThe solvents were evaporated
  2. dissolutionThe residue was dissolved in methylenechloride/MeOH 9:1 (100 ml)
  3. washwashed with 10 ml H2O
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-7848d36a203845ef871593c266a908c3
Source dataset
uspto-grants-2014_04
Patent number
US08703768B2

Reaction notes

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