(Phenylmethyl)hydrazine → HCID 57435375, compound

HRID 2368437Notes

Reaction equation

HRID 2368437 reaction equation
[C:1]([NH:9]/[C:10](/SC)=[N:11]/[C:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:22]([NH:29][NH2:30])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>CN(C=O)C.O>[CH2:22]([N:29]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:11][C:10]([NH:9][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[N:30]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

5

Reactant 2

HCID 11157(Phenylmethyl)hydrazineHCID 178503945HCID 178503945, compound

Product 1

HCID 57435375HCID 57435375, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a stirred solution of the crude (Z)-methyl N,N′-dibenzoylcarbamimidothioate (0.895 g, 3 mmol) in DMF (8 ml) was added benzylhydrazine (0.367 g, 3.00 mmol) at 40° C. The reaction was stirred for 2 days. The stirred reaction was diluted with water. The resulting precipitates were collected to yield the crude N-(1-benzyl-5-phenyl-1H-1,2,4-triazol-3-yl)benzamide. LCMS method A, (M+H)+355.1, ret T=1.32 min.

Workup

  1. customThe stirred reaction
  2. customThe resulting precipitates
  3. customwere collected

Sources & evidence

ORD record
ord-4b3238413bbd4de0837a3590797f9b68
Source dataset
uspto-grants-2014_04
Patent number
US08703761B2

Reaction notes

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