反应详情

温度

50 °C

To a solution of ethyl 1-(4-fluorophenyl)-2-mercapto-1H-imidazole-5-carboxylate (3) (2.62 g, 9.84 mmol) in 1,4-dioxane (21 mL) and methanol (10 mL) was added lithium hydroxide (825 mg, 19.7 mmol) in water (21 mL). The reaction was stirred at 50° C. overnight and the organic solvents were removed in vacuo. The mixture was acidified with 1M HCl until a white solid crashed out of the solution. The solid was collected by vacuum filtration and washed with water to afford 1-(4-fluorophenyl)-2-mercapto-1H-imidazole-5-carboxylic acid (4).

1. customthe organic solvents were removed in vacuo
2. filtrationThe solid was collected by vacuum filtration
3. washwashed with water