反应详情

温度

0 °C

To a solution of ethyl 1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazole-5-carboxylate (10) (1 g, 2.44 mmol) in THF at 0° C. was added lithium aluminum hydride (1M in THF, 4.88 mL, 4.88 mmol). The reaction was stirred for 1 h at 0° C. and at room temperature for 1 h. The solution was diluted with diethyl ether, and water (0.1 mL), 2N NaOH (0.1 mL), water (0.3 mL) and magnesium sulfate were added. The reaction was filtered and washed with THF to obtain (1-(4-fluorophenyl)-2-((2,3,6-trifluorobenzyl)thio)-1H-imidazol-5-yl)methanol (28) as a yellow oil.

1. additionwere added
2. filtrationThe reaction was filtered
3. washwashed with THF